Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp.

…, A Bolasco, R Fioravanti, P Chimenti, A Granese…

文献索引：Chimenti, Franco; Bizzarri, Bruna; Maccioni, Elias; Secci, Daniela; Bolasco, Adriana; Fioravanti, Rossella; Chimenti, Paola; Granese, Arianna; Carradori, Simone; Rivanera, Daniela; Lilli, Daniela; Zicari, Alessandra; Distinto, Simona Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 16 p. 4635 - 4640

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被引用次数: 47

摘要

In this paper, we report on the synthesis of a novel series of 2-thiazolylhydrazone derivatives and the influence of the substituents on the thiazole ring on antifungal activity. All synthesized compounds were screened for their in vitro activities against 22 clinical isolates of Candida spp., representing six different species, compared to clotrimazole as a reference compound. Some of the tested compounds were found to possess significant antifungal ...