A Brønsted acid-catalyzed method to prepare tri-and tetrasubstituted furans efficiently from cycloisomerization of but-2-yne-1, 4-diols with or without 1, 3-dicarbonyl compounds is described. By taking advantage of the orthogonal modes of reactivity of the alcoholic substrate through slight modification of the reaction conditions, a divergence in product selectivity was observed. At room temperature, p-TsOH· H2O-mediated tandem alkylation/ ...
