Synthesis of N-methyl secondary amines

…, JS Williamson, S Bhattacharyya

文献索引：Kumpaty, Hephzibah J.; Williamson, John S.; Bhattacharyya, Sukanta Synthetic Communications, 2003 , vol. 33, # 8 p. 1411 - 1416

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被引用次数: 37

摘要

View all references a method for the preparation of N-methyl secondary amines by reductive amination of carbonyl compounds using a combination of titanium(IV) isopropoxide and sodium borohydride. A mixture of methylamine hydrochloride and triethylamine has been employed as the source of nucleophilic methylamine. The method conveniently avoids the use of gaseous methylamine, however, the overall reaction was slow. ... View all references [6]14. ...