Highly chemoselective palladium-catalyzed conjugate reduction of. alpha.,. beta.-unsaturated carbonyl compounds with silicon hydrides and zinc chloride cocatalyst

E Keinan, N Greenspoon

文献索引：Keinan, Ehud; Greenspoon, Noam Journal of the American Chemical Society, 1986 , vol. 108, # 23 p. 7314 - 7325

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被引用次数: 131

摘要

Abstract: A three-component system comprised of a soluble palladium catalyst, hydridosilane, and zinc chloride is capable of efficient conjugate reduction of a, &unsaturated ketones and aldehydes. The optimal set of conditions includes diphenylsilane as the most effective hydride donor, any soluble palladium complex in either the 0 or I1 oxidation state, when it is stabilized by phosphine ligands, and ZnCll as the best Lewis ...