Discovery of a novel chemotype of potent human ENaC blockers using a bioisostere approach. Part 2: α-Branched quaternary amines

T Hunt, HC Atherton-Watson, SP Collingwood…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 8 p. 2877 - 2879

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被引用次数: 13

摘要

... Bioorganic & Medicinal Chemistry Letters. ... 1 Current marketed therapeutics only target the infection and inflammation symptoms of CF, as such there is an unmet medical need for novel treatments that address the underlying cause of CF. ...