Synthesis of N-desmethyl derivatives of 17α-acetoxy-11β-(4-N, N-dimethylaminophenyl)-19-norpregna-4, 9-diene-3, 20-dione and mifepristone 1: Substrates for the …
PN Rao, CK Acosta, JW Cessac, ML Bahr, HK Kim
文献索引：Rao, Pemmaraju N.; Acosta, C. Kirk; Cessac, James W.; Bahr, Martin L.; Kim, Hyun K. Steroids, 1999 , vol. 64, # 3 p. 205 - 212
The syntheses of N-desmethyl derivatives of CDB-2914 and the mono-N-desmethyl derivative of Mifepristone are described. We also describe the use of the mono-desmethyl derivatives as substrates for the synthesis of N-tritomethyl derivatives of CDB-2914 and Mifepristone with high specific activity (ca. 80 Ci/mmol), which serve as radioligands for radioimmunoassay.
