5-imino-1, 2, 4-thiadiazoles: first small molecules as substrate competitive inhibitors of glycogen synthase kinase 3

…, A Castro, NE Campillo, A Perez-Castillo…

文献索引：Palomo, Valle; Perez, Daniel I.; Perez, Concepcion; Morales-Garcia, Jose A.; Soteras, Ignacio; Alonso-Gil, Sandra; Encinas, Arantxa; Castro, Ana; Campillo, Nuria E.; Perez-Castillo, Ana; Gil, Carmen; Martinez, Ana Journal of Medicinal Chemistry, 2012 , vol. 55, # 4 p. 1645 - 1661

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被引用次数: 40

摘要

Cumulative evidence strongly supports that glycogen synthase kinase-3 (GSK-3) is a pathogenic molecule when it is up-dysregulated, emerging as an important therapeutic target in severe unmet human diseases. GSK-3 specific inhibitors might be promising effective drugs for the treatment of devastating pathologies such as neurodegenerative diseases, stroke, and mood disorders. As GSK-3 has the ability to phosphorylate primed ...