Synthesis of. beta.-lactams from substituted hydroxamic acids

…, PG Mattingly, MA Morrison, JF Kerwin Jr

文献索引：Miller; Mattingly; Morrison; Kerwin Jr. Journal of the American Chemical Society, 1980 , vol. 102, # 23 p. 7026 - 7032

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被引用次数: 162

摘要

Abstract: An efficient biomimetic p-lactam synthesis has been developed on the basis of cyclization of substituted 8-hydroxyhydroxamic acids. The method is experimentally simple and, by appropriate choice of amino acid starting material, allows complete control of the stereochemistry at all positions of the p-lactam. The method is also compatible with the incorporation of sensitive peripheral functionality required for potential elaboration to ...