Tetrahedron letters

Synthesis of novel N-(primary) alkylhydroxamic acids

L Grierson, MJ Perkins

文献索引：Grierson, Lebert; Perkins, M. John Tetrahedron Letters, 1993 , vol. 34, # 46 p. 7463 - 7464

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被引用次数: 9

摘要

Synthesis of N-primary alkylhydroxamic acids is described in this paper by benzoyloxylation (benzoyl peroxide) of n-alkylamine and modification of the usual reaction conditions to stabilise the -alkyl- -benzoylhydroxylamine as the hydrochloride; this circumvents acyl transfer to amide. -Acylation of the formed hydroxylamine leads to the formation of N-primary alkyl- -acyl- -acylhydroxylamine, which is debenzoylated to hydroxamic acid using hydrazine ...