Preparation and Characterization of [5??13C]??(2S, 4R)??Leucine and [4??13C]??(2S, 3S)??Valine− Establishing Synthetic Schemes to Prepare Any Site??Directed …

…, WS Woo, J Lugtenburg

文献索引：Siebum, Arjan H. G.; Woo, Wei Sein; Lugtenburg, Johan European Journal of Organic Chemistry, 2003 , # 23 p. 4664 - 4678

全文：HTML全文

被引用次数: 14

摘要

Abstract In this paper a chemo-enzymatic method has been developed that gives access to any isotopomer of the essential amino acids isoleucine and valine. The method gives the correct introduction of the second chiral center in (2S, 3S)-isoleucine and allows for discrimination between the two prochiral methyl groups in valine as shown by the preparation of (2S, 3S)-[4-13 C] valine. For the preparation of (2S)-leucine in any ...