The amide bond is a key functional group in organic chemistry. It plays an important role in the composition of polymers, proteins, natural products, and pharmaceuticals. 1 The most common synthetic route to these nitrogen-containing compounds relies heavily on the reactions of activated carboxylic acids and their derivatives with amines. 2 However, this method has the innate drawbacks, for instance, a large amount of byproducts are generated and the activated ...
