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Activated N-nitrosocarbamates for regioselective synthesis of N-nitrosoureas

…, J Oiry, JL Imbach, F Winternitz

文献索引：Martinez, Jean; Oiry, Joel; Imbach, Jean Louis; Winternitz, Francois Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 178 - 182

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被引用次数: 63

摘要

A practical and convenient method for synthesizing antitumor compounds, N-alkyl-N- nitrosoureas, regioselectively nitrosated on the nitrogen atom bearing the alkyl group is proposed. N-Alkyl-N-nitrosocarbamates are interesting intermediates in these syntheses and yield, by reaction with amino compounds, the regioselectively nitrosated N-alkyl-N- nitrosoureas. As an interesting example, N, N'-bis [(2-chloroethyl) nitrosocarbamoyl] ...

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