Enzymic aldol condensation/isomerization as a route to unusual sugar derivatives

JR Durrwachter, DG Drueckhammer…

文献索引：Durrwachter,J.; Drueckhammer,D.; Nozaki,K. Journal of the American Chemical Society, 1986 , vol. 108, p. 7812

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被引用次数: 119

摘要

Abstract: Preparative enzymatic synthesis of several unusual hexoketose and hexoaldose derivatives using fructose bisphosphate aldolase and glucose isomerase as catalysts has been developed. Fructose bisphosphate aldolase catalyzes a stereospecific aldol condensation between dihydroxyacetone phosphate and a number of aldehydes to form ketose 1-phosphates which upon removal of the phosphate groups by hydrolysis are ...