Tetrahedron Letters

Indium triflate-catalyzed one-pot synthesis of 1-substituted-1H-1, 2, 3, 4-tetrazoles under solvent-free conditions

D Kundu, A Majee, A Hajra

文献索引：Kundu, Dhiman; Majee, Adinath; Hajra, Alakananda Tetrahedron Letters, 2009 , vol. 50, # 22 p. 2668 - 2670

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被引用次数: 60

摘要

A simple, efficient, and general method has been developed for the synthesis of 1- substituted-1H-1, 2, 3, 4-tetrazoles via a three-component condensation of amine, trimethyl orthoformate, and sodium azide in presence of a catalytic amount of indium triflate under solvent-free conditions. The reaction proceeds smoothly to generate the corresponding 1- substituted tetrazoles in moderate to excellent yields under heating.