Medicinal Chemistry Research

Synthesis and evaluation in vitro of 1-[2-(10-dihydroartemisininoxy) ethyl]-3-phenylurea derivatives as potential agents against cancer

W Luo, M Xia, T Ikejima, L Li, C Guo

文献索引：Luo, Wei; Xia, Ming-Yu; Ikejima, Takashi; Li, Li-Hua; Guo, Chun Medicinal Chemistry Research, 2013 , vol. 22, # 7 p. 3170 - 3176

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摘要

Abstract In order to develop potent and selective anticancer agents, a series of novel artemisinin derivatives bearing urea moiety 1a–n were facilely synthesized herein and screened for their activities in vitro against ten human tumor cell lines (HeLa, MCF-7, U937, K562, HL60, HCT116, HepG2, A549, A375-S2, and HT1080). The pharmacological results indicated that some compounds showed excellent activity against cancer cell lines and ...