Tetrahedron Letters

Regioselectivity in isoquinoline alkaloid synthesis

R Quevedo, E Baquero, M Rodriguez

文献索引：Quevedo, Rodolfo; Baquero, Edwin; Rodriguez, Mario Tetrahedron Letters, 2010 , vol. 51, # 13 p. 1774 - 1778

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被引用次数: 17

摘要

Regioselectivity in isoquinoline alkaloid synthesis is analyzed here. Our experiments have shown that substituents on the aromatic ring of the starting amine are determinant in isoquinoline synthesis. The use of dicyclohexylcarbodiimide in activating carboxylic acids for electrophilic aromatic substitution reactions is presented for the first time.