Imidazoles frequently are found in biologically active natural products or pharmaceutically important drugs. 1 Our interest in the search for new receptor tyrosine kinase inhibitors 2 has been focusing on the synthesis of 2-quinolinone core derivatives 5 with C-3 imidazole moiety (Fig. 1). The quinolin-2(1H)-one-3-imidazoles 5 were readily prepared by condensing 2-imidazol-2-ylacetate 3 with various substituted 2-aminobenzaldehydes 4. 3 Several methods for the synthesis ...
