Tetrahedron letters

Efficient synthesis of 2-imidazol-2-ylacetates

J Du Ha, SJ Lee, SY Nam, SK Kang, SY Cho, JH Ahn…

Index: Ha, Jae Du; Lee, Su Jung; Nam, So Yeun; Kang, Seung Kyu; Cho, Seung Yoon; Ahn, Jin Hee; Choi, Joong-Kwon Tetrahedron Letters, 2006 , vol. 47, # 35 p. 6201 - 6204

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Citation Number: 7

Abstract

Imidazoles frequently are found in biologically active natural products or pharmaceutically important drugs. 1 Our interest in the search for new receptor tyrosine kinase inhibitors 2 has been focusing on the synthesis of 2-quinolinone core derivatives 5 with C-3 imidazole moiety (Fig. 1). The quinolin-2(1H)-one-3-imidazoles 5 were readily prepared by condensing 2-imidazol-2-ylacetate 3 with various substituted 2-aminobenzaldehydes 4. 3 Several methods for the synthesis ...