Bioorganic & medicinal chemistry

Synthesis of daidzin analogues as potential agents for alcohol abuse

GY Gao, DJ Li, WM Keung

文献索引：Gao, Guang-Yao; Li, Dian-Jun; Keung, Wing Ming Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 4069 - 4081

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被引用次数: 35

摘要

Daidzin, the active principle of an herbal remedy for 'alcohol addiction', has been shown to reduce alcohol consumption in all laboratory animals tested to date. Correlation studies using structural analogues of daidzin suggests that it acts by raising the monoamine oxidase (MAO)/mitochondrial aldehyde dehydrogenase (ALDH-2) activity ratio (J. Med. Chem. 2000, 43, 4169). Structure–activity relationship (SAR) studies on the 7-O-substituted analogues ...