7-甲氧基异黄酮

• 常用名: 7-甲氧基异黄酮
• 英文名: 7-Methoxyisoflavone
• CAS号: 1621-56-3
• 分子量: 252.26500
• 密度: 1.24g/cm3
• 沸点: 421.2ºC at 760 mmHg
• 分子式: C₁₆H₁₂O₃
• 熔点: N/A
• 闪点: 200.3ºC

7-甲氧基异黄酮用途

7-Methoxyisoflavone 是异黄酮衍生物,也是腺苷一磷酸激活的蛋白激酶 (AMPK) 的激活剂。

7-甲氧基异黄酮名称

• 中文名: 7-甲氧基异黄酮
• 英文名: 7-methoxy-3-phenylchromen-4-one

7-甲氧基异黄酮生物活性

• 描述: 7-Methoxyisoflavone 是异黄酮衍生物,也是腺苷一磷酸激活的蛋白激酶 (AMPK) 的激活剂。
• 相关类别:
  信号通路 >> 表观遗传学 >> AMPK
  信号通路 >> PI3K/Akt/mTOR 信号通路 >> AMPK
  研究领域 >> 癌症
  天然产物 >> 黄酮类化合物
  研究领域 >> 代谢疾病
• 靶点实验:

  AMPK[1]

• 体外研究: 7-甲氧基异黄酮是一种异黄酮衍生物,也是腺苷一磷酸激活蛋白激酶(AMPK)的激活剂。当血清饥饿的细胞在7-甲氧基异黄酮存在下用10％FBS处理时,血清诱导的AMPK磷酸化降低被阻止[1]。
• 参考文献:

  [1]. Hyeryoung Jung, et al. Isoflavones as modulators of adenosine monophosphate-activated protein kinase. Applied Biological Chemistry. 2016. 59, 217-225.

7-甲氧基异黄酮物理化学性质

• 密度: 1.24g/cm3
• 沸点: 421.2ºC at 760 mmHg
• 分子式: C₁₆H₁₂O₃
• 分子量: 252.26500
• 闪点: 200.3ºC
• 精确质量: 252.07900
• PSA: 39.44000
• LogP: 3.46860
• InChIKey: IECSQLKWZBEUGA-UHFFFAOYSA-N
• SMILES: COc1ccc2c(=O)c(-c3ccccc3)coc2c1
• 蒸汽压: 2.66E-07mmHg at 25°C
• 折射率: 1.614
• 储存条件: 2-8℃

7-甲氧基异黄酮安全信息

• 海关编码: 2932999099

7-甲氧基异黄酮海关

• 海关编码: 2914509090
• 中文概述: 2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

7-甲氧基异黄酮靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Dicer-mediated maturation of pre-microRNA 来源：Center for Chemical Genomics, University of Michigan 靶标：N/A External Id：TargetID_659_CEMA

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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7-甲氧基异黄酮英文别名

• 7-methoxy-3-phenylchromone
• 7-Methoxy-3-phenyl-chromen-4-on
• 7-methoxy-3-phenyl-4H-1-benzopyran-4-one
• 7-methoxy-3-phenyl-4H-chromen-4-one
• 7-Methoxy Isoflavone
• 7-methoxy-3-phenyl-chromen-4-one
• 7-Methoxyisoflavone