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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthesis of deuterium??labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its …

…, MS Bednarz, JJ Hangeland, SZ Ahmed…

文献索引：Chen, Bang-Chi; Sundeen, Joseph E.; Guo, Peng; Bednarz, Mark S.; Hangeland, Jon J.; Ahmed, Syed Z.; Jemal, Mohammed Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 3 p. 261 - 270

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被引用次数: 11

摘要

Abstract D 5-labeled isotopomers of atorvastatin, atorvastatin lactone and its hydroxy metabolites were synthesized as internal standards for use in a LC/MS/MS method developed for the simultaneous quantitative determination of atorvastatin and its hydroxy metabolites in human serum. d 5-Atorvastatin and d 5-atorvastatin lactone were prepared from d 5-aniline whereas their corresponding hydroxy metabolites were synthesized using ...

2-Benzyloxy Atorvastatin-d5 Acetonide tert-Butyl Ester结构式

2-Benzyloxy Ato...

~81%

tert-butyl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-4-[(2-hydroxyphenyl)carbamoyl]-3-(2,3,4,5,6-pentadeuteriophenyl)-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate结构式

tert-butyl 2-[(...

2-苄氧基苯胺结构式

2-苄氧基苯胺

~%

tert-butyl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-4-[(2-hydroxyphenyl)carbamoyl]-3-(2,3,4,5,6-pentadeuteriophenyl)-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate结构式

tert-butyl 2-[(...

1-苄氧基-2-硝基苯结构式

1-苄氧基-2-硝基苯

~%

tert-butyl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-4-[(2-hydroxyphenyl)carbamoyl]-3-(2,3,4,5,6-pentadeuteriophenyl)-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate结构式

tert-butyl 2-[(...

N-2-苄氧基苯基异丁酰基乙酰胺结构式

N-2-苄氧基苯基异丁酰基乙酰胺

~%

tert-butyl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-4-[(2-hydroxyphenyl)carbamoyl]-3-(2,3,4,5,6-pentadeuteriophenyl)-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate结构式

tert-butyl 2-[(...

N-2-苄氧基苯基-α-苄基-d5-异丁酰基乙酰胺结构式

N-2-苄氧基苯基-α-苄基-...

~%

tert-butyl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-4-[(2-hydroxyphenyl)carbamoyl]-3-(2,3,4,5,6-pentadeuteriophenyl)-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate结构式

tert-butyl 2-[(...

2-[2-(4-fluorophenyl)-2-oxo-1-(2,3,4,5,6-pentadeuteriophenyl)ethyl]-4-methyl-3-oxo-N-(2-phenylmethoxyphenyl)pentanamide结构式

2-[2-(4-fluorop...

~%

tert-butyl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-4-[(2-hydroxyphenyl)carbamoyl]-3-(2,3,4,5,6-pentadeuteriophenyl)-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate结构式

tert-butyl 2-[(...

1-苄氧基-2-硝基苯结构式

1-苄氧基-2-硝基苯

~%

N-2-苄氧基苯基异丁酰基乙酰胺结构式

N-2-苄氧基苯基异丁酰基乙酰胺

4-苄氧基苯胺结构式

4-苄氧基苯胺

~%

2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic Acid, (4-Benzyloxy-phenyl)-amide结构式

2-[2-(4-Fluorop...

N-4-苄氧基苯基异丁酰基乙酰胺结构式

N-4-苄氧基苯基异丁酰基乙酰胺

~%

2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic Acid, (4-Benzyloxy-phenyl)-amide结构式

2-[2-(4-Fluorop...

2-苄氧基苯胺结构式

2-苄氧基苯胺

~%

2-羟基阿托伐他汀结构式

2-羟基阿托伐他汀

1-苄氧基-2-硝基苯结构式

1-苄氧基-2-硝基苯

~%

2-羟基阿托伐他汀结构式

2-羟基阿托伐他汀

N-2-苄氧基苯基异丁酰基乙酰胺结构式

N-2-苄氧基苯基异丁酰基乙酰胺

~%

2-羟基阿托伐他汀结构式

2-羟基阿托伐他汀

N-2-苄基氧基苯基α-苄叉异丁酰基乙酰胺结构式

N-2-苄基氧基苯基α-苄叉异...

~%

2-羟基阿托伐他汀结构式

2-羟基阿托伐他汀

2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic Acid, (2-Benzyloxy-phenyl)-amide结构式

2-[2-(4-Fluorop...

~%

2-羟基阿托伐他汀结构式

2-羟基阿托伐他汀

(6-{2-[2-(4-Fluoro-phenyl)-4-(2-hydroxy-phenylcarbamoyl)-5-isopropyl-3-phenyl-pyrrol-1-yl]-ethyl}-2,2-dimethyl-[1,3]-dioxane-4-yl)-acetic Acid, tert-Butyl Ester结构式

(6-{2-[2-(4-Flu...

~%

2-羟基阿托伐他汀结构式

2-羟基阿托伐他汀

苯胺-2,3,4,5,6-d5结构式

苯胺-2,3,4,5,6-d5

~%

2-Methyl-2-propanyl [6-(2-{2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(2H5)phenylcarbamoyl]-1H-pyrrol-1-yl}ethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate结构式

2-Methyl-2-prop...

N-d5-phenyl isobutyrylacetamide结构式

N-d5-phenyl iso...

~%

2-Methyl-2-propanyl [6-(2-{2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(2H5)phenylcarbamoyl]-1H-pyrrol-1-yl}ethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate结构式

2-Methyl-2-prop...

N-4-苯基α-亚苄基-d5异丁酰基乙酰胺结构式

N-4-苯基α-亚苄基-d5异...

~%

2-Methyl-2-propanyl [6-(2-{2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(2H5)phenylcarbamoyl]-1H-pyrrol-1-yl}ethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate结构式

2-Methyl-2-prop...

tert-butyl 2-((4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate结构式

tert-butyl 2-((...

2-(2-(4-fluorophenyl)-2-oxo-1-phenylethyl)-4-methyl-3-oxo-N-(phenyl-d5)pentanamide结构式

2-(2-(4-fluorop...

~%

2-Methyl-2-propanyl [6-(2-{2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(2H5)phenylcarbamoyl]-1H-pyrrol-1-yl}ethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate结构式

2-Methyl-2-prop...

2-苄氧基苯胺结构式

2-苄氧基苯胺

~%

2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic Acid, (2-Benzyloxy-phenyl)-amide结构式

2-[2-(4-Fluorop...

1-苄氧基-2-硝基苯结构式

1-苄氧基-2-硝基苯

~%

2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic Acid, (2-Benzyloxy-phenyl)-amide结构式

2-[2-(4-Fluorop...

N-2-苄氧基苯基异丁酰基乙酰胺结构式

N-2-苄氧基苯基异丁酰基乙酰胺

~%

2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic Acid, (2-Benzyloxy-phenyl)-amide结构式

2-[2-(4-Fluorop...

对氟苯甲醛结构式

对氟苯甲醛

N-2-苄基氧基苯基α-苄叉异丁酰基乙酰胺结构式

N-2-苄基氧基苯基α-苄叉异...

~%

2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic Acid, (2-Benzyloxy-phenyl)-amide结构式

2-[2-(4-Fluorop...

4-苄氧基苯胺结构式

4-苄氧基苯胺

~%

tert-butyl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-[(4-phenylmethoxyphenyl)carbamoyl]-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate结构式

tert-butyl 2-[(...

N-4-苄氧基苯基异丁酰基乙酰胺结构式

N-4-苄氧基苯基异丁酰基乙酰胺

~%

tert-butyl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-[(4-phenylmethoxyphenyl)carbamoyl]-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate结构式

tert-butyl 2-[(...

N-4-苄基氧基苯基α-苄叉异丁酰基乙酰胺结构式

N-4-苄基氧基苯基α-苄叉异...

~%

tert-butyl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-[(4-phenylmethoxyphenyl)carbamoyl]-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate结构式

tert-butyl 2-[(...

tert-butyl 2-((4R,6R)-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate结构式

tert-butyl 2-((...

2-[2-(4-Fluorophenyl)-2-oxo-1-phenyl-ethyl]-4-methyl-3-oxo-pentanoic Acid, (4-Benzyloxy-phenyl)-amide结构式

2-[2-(4-Fluorop...

~%

tert-butyl 2-[(4R,6R)-6-[2-[2-(4-fluorophenyl)-3-phenyl-4-[(4-phenylmethoxyphenyl)carbamoyl]-5-propan-2-ylpyrrol-1-yl]ethyl]-2,2-dimethyl-1,3-dioxan-4-yl]acetate结构式

tert-butyl 2-[(...

苯胺-2,3,4,5,6-d5结构式

苯胺-2,3,4,5,6-d5

~%

N-4-苯基α-亚苄基-d5异丁酰基乙酰胺结构式

N-4-苯基α-亚苄基-d5异...

苯甲醛结构式

N-d5-phenyl isobutyrylacetamide结构式

N-d5-phenyl iso...

~%

N-4-苯基α-亚苄基-d5异丁酰基乙酰胺结构式

N-4-苯基α-亚苄基-d5异...