Isomeric monomethyl ether derivatives of (RS)-9, 10-dihydroxyaporphine (" isoapomorphine") as possible products of metabolism by catechol-O-methyltransferase
JG Cannon, P Qijie
文献索引：Cannon, Joseph G.; Qijie, Pang Journal of Medicinal Chemistry, 1991 , vol. 34, # 3 p. 1079 - 1082
The isomeric monomethyl ether derivatives of (RS)-9, 10-dihydroxyaporphine (“isoapomorphine”) were synthesized unequivocally as possible metabolites in catechol-0- methyltransferase (COMT) mediated 0-methylation reactions. In vitro incubation studies revealed that isoapomorphine is not a substrate for the COMT using experimental conditions under which apomorphine (10, ll-dihydroxyaporphine) is converted in high yield into its 10 ...
