Journal of Fluorine Chemistry

Microwave-assisted amination from fluorobenzenes without catalyst and strong base

X Meng, Z Cai, S Xiao, W Zhou

文献索引：Meng, Xiangguo; Cai, Zhengyan; Xiao, Sa; Zhou, Weicheng Journal of Fluorine Chemistry, 2013 , vol. 146, p. 70 - 75

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被引用次数: 3

摘要

A facile and versatile amination of fluorobenzenes has been developed in good to excellent yields under microwave irradiation in N-methylpyrrolidinone (NMP) without strong base and catalyst. The presence of additional halogen atom (s) enhanced the leaving ability of fluorine and meta fluorine gave higher activation than the ortho. It is remarkable that 1, 2, 3- trifluorobenzene, 1, 2, 4-trifluorobenzene and 1, 2, 4, 5-tetrafluorobenzene can produce ...