Arylpiperazines displaying preferential potency against chloroquine-resistant strains of the malaria parasite Plasmodium falciparum

CA Molyneaux, M Krugliak, H Ginsburg…

文献索引：Molyneaux, Carrie-Anne; Krugliak, Miriam; Ginsburg, Hagai; Chibale, Kelly Biochemical Pharmacology, 2005 , vol. 71, # 1-2 p. 61 - 68

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被引用次数: 21

摘要

Arylpiperazines in which the terminal secondary amino group is unsubstituted were found to display a mefloquine-type antimalarial behavior in being significantly more potent against the chloroquine-resistant (W2 and FCR3) strains of Plasmodium falciparum than against the chloroquine-sensitive (D10 and NF54) strains. Substitution of the aforementioned amino group led to a dramatic drop in activity across all strains as well as abolition of the ...

41202-32-8

1-(2-氯苯基)哌嗪盐酸盐

~90%

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1-(2-氯苯基)哌嗪

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