Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl] amino} pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors

S Nagashima, M Yokota, E Nakai, S Kuromitsu…

文献索引：Nagashima, Shinya; Yokota, Masaki; Nakai, Ei-ichi; Kuromitsu, Sadao; Ohga, Keiko; Takeuchi, Makoto; Tsukamoto, Shin-ichi; Ohta, Mitsuaki Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 1044 - 1055

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被引用次数: 27

摘要

The STAT6 (signal transducers and activators of transcription 6) protein is activated by interleukin (IL)-4 and IL-13, and plays an important role in T-helper cell 2 (Th2) differentiation. STAT6 might therefore be an excellent therapeutic target for various allergic conditions, including asthma and atopic diseases. We synthesized a series of 2-{[2-(4- hydroxyphenyl) ethyl] amino} pyrimidine-5-carboxamide derivatives and evaluated their ...