Enantioselective N–H Functionalization of Indoles with α, β??Unsaturated γ??Lactams Catalyzed by Chiral Brønsted Acids

Y Xie, Y Zhao, B Qian, L Yang, C Xia…

文献索引：Xie, Yinjun; Zhao, Yingwei; Qian, Bo; Yang, Lei; Xia, Chungu; Huang, Hanmin Angewandte Chemie - International Edition, 2011 , vol. 50, # 25 p. 5682 - 5686

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被引用次数: 54

摘要

Chiral indole motifs are privileged heterocyclic structures in drug discovery and widely exist in synthetic bioactive compounds and natural products.[1] Therefore, intense effort has been devoted to the direct enantioselective functionalization of indole cores for the synthesis of optically active indole derivatives.[2] While many asymmetric alkylation methods exist for the functionalization of indoles at the C3 or C2 atom,[3] the asymmetric functionalization of ...