Biomimetic approach to potential benzodiazepine receptor agonists and antagonists

F Guzman, M Cain, P Larscheid, T Hagen…

文献索引：Guzman; Cain; Larscheid; Hagen; Cook; Schweri; Skolnick; Paul Journal of Medicinal Chemistry, 1984 , vol. 27, # 5 p. 564 - 570

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被引用次数: 52

摘要

Recently, it has been demonstratedlP16 that 0-CCE antagonizes the anticonvulsant actions of diazepam, lowers the seizure threshold of the convulsant pentylenetetrazole (PTZ), antagonizes the sedative actions of flurazepam, and is anxiogenic. l'A closely related compound, 3-(hydroxymethyl)-p-carboline, l0 was shown to antagonize both the anticonvulsant and anxiolytic actions of diazepam at doses that do not exert overt ...