Synthesis and antidopaminergic activity of some 3-(aminomethyl) tetralones as analogs of butyrophenone

L Cortizo, L Santana, E Ravina, F Orallo…

文献索引：Cortizo; Santana; Ravina; Orallo; Fontenla; Castro; Calleja; De Ceballos Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2242 - 2247

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被引用次数: 40

摘要

Starting from fl-benzoylpropionic acid we synthesized 3-(aminomethyl) tetralones in which the amino substituent was d (N-piperaziny1)-p-fluorobutyrophenone (14), 4benzoylpiperidine (15), 4-hydroxy-4phenylpiperidine (16) or d (o-methoxypheny1) piperazine (17). The poesible dopamine antagonist activity of theae compounds was investigated in both 'in vitro” and 'in vivo” experiments. These compounds potently ...