Synthesis and antidopaminergic activity of some 3-(aminomethyl) tetralones as analogs of butyrophenone

L Cortizo, L Santana, E Ravina, F Orallo…

Index: Cortizo; Santana; Ravina; Orallo; Fontenla; Castro; Calleja; De Ceballos Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2242 - 2247

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Citation Number: 40

Abstract

Starting from fl-benzoylpropionic acid we synthesized 3-(aminomethyl) tetralones in which the amino substituent was d (N-piperaziny1)-p-fluorobutyrophenone (14), 4benzoylpiperidine (15), 4-hydroxy-4phenylpiperidine (16) or d (o-methoxypheny1) piperazine (17). The poesible dopamine antagonist activity of theae compounds was investigated in both 'in vitro” and 'in vivo” experiments. These compounds potently ...

 Related Synthetic Route
Piperazine Structure

110-85-0

Piperazine

4-Chloro-p-fluorobutyrophenone Structure

3874-54-2

4-Chloro-p-fluo...

~86%

1-(4-FLUORO-PHENYL)-4-PIPERAZIN-1-YL-BUTAN-1-ONE Structure

2560-31-8

1-(4-FLUORO-PHE...

1-(3,5-DIMETHYL-PHENYL)-PYRROLE-2,5-DIONE Structure

55846-41-8

1-(3,5-DIMETHYL...

~%

1-(4-FLUORO-PHENYL)-4-PIPERAZIN-1-YL-BUTAN-1-ONE Structure

2560-31-8

1-(4-FLUORO-PHE...

2-(3-Chloropropyl)-2-(4-fluorophenyl)-1,3-dioxolane Structure

3308-94-9

2-(3-Chloroprop...

~%

1-(4-FLUORO-PHENYL)-4-PIPERAZIN-1-YL-BUTAN-1-ONE Structure

2560-31-8

1-(4-FLUORO-PHE...


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