Dopaminergic activity of substituted 6-chloro-1-phenyl-2, 3, 4, 5-tetrahydro-1H-3-benzazepines

…, J Weinstock, GY Kuo, PA Chambers…

文献索引：Pfeiffer; Wilson; Weinstock; Kuo; Chambers; Holden; Hahn; Wardell Jr.; Tobia; Setler; Sarau Journal of Medicinal Chemistry, 1982 , vol. 25, # 4 p. 352 - 358

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被引用次数: 52

摘要

6-Chloro-7, 8dihydroxy-1-phenyl-2, 3, 4, 5-tetrahydro-1H-3-benzazepines were synthesized and evaluated as agonists of central and peripheral dopamine receptors. These benzazepines were prepared by cyclization of certain amino alcohols followed by demethylation of the 7, 8-dimethoxy groups of the precursors to the 78-catecholic moiety. Preliminary evidence of dopaminergic activity was determined in anesthetized dogs by ...