Regioselective synthesis of 1-alkyl-5-(indol-3-yl-and-2-yl) pyrrolidin-2-ones from available reagents

…, AE Kovrov, GA Golubeva, LA Sviridova

文献索引：Sadovoy; Kovrov; Golubeva; Sviridova Chemistry of Heterocyclic Compounds, 2011 , vol. 46, # 10 p. 1215 - 1223

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被引用次数: 6

摘要

The reaction under mild conditions of 1-alkyl-5-hydroxypyrrolidin-2-ones with different indoles having a free 3 position leads exclusively to 1-alkyl-5-(indol-3-yl)pyrrolidin-2-ones but if position 3 is occupied to 1-alkyl-5-(indol-2-yl)pyrrolidin-2-ones. ... Keywords: 1-alkyl-5-hydroxypyrrolidin -2-ones, 1-alkyl-5-indolylpyrrolidin-2-ones, indoles, amido- alkylation. ... It is known that the combination of pharmacophoric fragments in a single molecule often leads to a strengthening and/or ...