Tetrahedron Letters

Friedel–Crafts acylation of aromatic compounds with carboxylic acids in the presence of P 2 O 5/SiO 2 under heterogeneous conditions

A Zarei, AR Hajipour, L Khazdooz

文献索引：Zarei, Amin; Hajipour, Abdol R.; Khazdooz, Leila Tetrahedron Letters, 2008 , vol. 49, # 47 p. 6715 - 6719

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被引用次数: 27

摘要

A convenient and efficient procedure for the Friedel–Crafts acylation of aromatic compounds with carboxylic acids in the presence of P2O5/SiO2 is described. Both aromatic and aliphatic carboxylic acids reacted easily to afford the corresponding aromatic ketones. The use of non- toxic and inexpensive materials, simple and clean work-up, short reaction times and good yields of the products are the advantages of this method.