Chemosphere

Synthesis of hydroxylated PCB metabolites with the Suzuki-coupling

HJ Lehmler, LW Robertson

文献索引：Lehmler, Hans-Joachim; Robertson, Larry W. Chemosphere, 2001 , vol. 45, # 8 p. 1119 - 1127

全文：HTML全文

被引用次数: 68

摘要

An improved synthesis of hydroxylated polychlorinated biphenyls (PCBs) which are structurally related to the major hydroxy PCB congeners identified in human plasma is described. The coupling of (chlorinated) aryl boronic acids with bromochloro anisoles using the standard conditions of the Suzuki coupling gave the desired hydroxylated PCB metabolites in good to excellent yields. The approach offers the advantage of high ...