Pilot-Scale Production of Dimethyl 1, 4-Cubanedicarboxylate

…, KJ McRae, GP Savage, J Tsanaktsidis

文献索引：Falkiner, Michael J.; Littler, Stuart W.; McRae, Kenneth J.; Savage, G. Paul; Tsanaktsidis, John Organic Process Research and Development, 2013 , vol. 17, # 12 p. 1503 - 1509

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被引用次数: 6

摘要

A scalable process for the preparation of high purity dimethyl 1, 4-cubanedicarboxylate (3) is reported. The work described herein builds on previous synthetic work from this and other laboratories, to provide a reliable process that can be used to prepare multigram quantities of 3 in a partially telescoped, 8 step process, with minimal purification of intermediates.