Structure–activity relationships of N-substituted 4-(trifluoromethoxy) benzamidines with affinity for GluN2B-containing NMDA receptors

C Beinat, SD Banister, J Hoban, J Tsanaktsidis…

文献索引：Beinat, Corinne; Banister, Samuel D.; Hoban, Jane; Tsanaktsidis, John; Metaxas, Athanasios; Windhorst, Albert D.; Kassiou, Michael Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 828 - 830

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被引用次数: 2

摘要

Abstract GluN2B subtype-selective NMDA antagonists represent promising therapeutic targets for the symptomatic treatment of multiple CNS pathologies. A series of N-benzyl substituted benzamidines were synthesised and the benzyl ring was further replaced with ...