Benzofuroxane derivatives as multi-effective agents for the treatment of cardiovascular diabetic complications. Synthesis, functional evaluation, and molecular …

…, F Da Settimo, E Novellino, C La Motta

文献索引：Ramunno, Anna; Cosconati, Sandro; Sartini, Stefania; Maglio, Vita; Angiuoli, Sara; La Pietra, Valeria; Di Maro, Salvatore; Giustiniano, Mariateresa; La Motta, Concettina; Da Settimo, Federico; Marinelli, Luciana; Novellino, Ettore European Journal of Medicinal Chemistry, 2012 , vol. 51, p. 216 - 226

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被引用次数: 12

摘要

Diabetes mellitus is the major risk factor for cardiovascular disorders. Aldose reductase, the rate-limiting enzyme of the polyol pathway, plays a key role in the pathogenesis of diabetic complications. Accordingly, inhibition of this enzyme is emerging as a major therapeutic strategy for the treatment of hyperglycemia-induced cardiovascular pathologies. In this study, we describe a series of 5 (6)-substituted benzofuroxane derivatives, 5a–k, m, ...