Herein we want to report a new, more general “amide” version of the Petasis reaction using a cooperative dual catalyst system capable of combining nucleophilic and electrophilic activation.(10) Our initial idea was to generate the reactive acyl imine in situ via an acid-mediated condensation between an amide and an aldehyde(11) and to use a suitable transition metal to activate simple commercial available arylboronic acids for addition to the formed ...
