Metabolism of phenazepam in the rat organism

…, VG Zin'kovskii, AV Bogatskii, PA Sharbatyan…

文献索引：Golovenko, N. Ya.; Zin'kovskii, V. G.; Bogatskii, A. V.; Sharbatyan, P. A.; Andronati, S. A. Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 4 p. 208 - 213 Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 4 p. 15 - 21

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摘要

In previous studies [i, 2] we showed that in the bodies of white rats phenazepam is hydroxylated with the formation of metabolites containing the hydroxyl group in the 3- position and in the aromatic rings. In the indicated studies, the direction of the aromatic hydroxylation of phenazepam was not established. The purpose of the present investigation was a detailed study of the structure of the metabolites of phenazepam formed in the ...