3-羟基芬纳西泮

• 常用名: 3-羟基芬纳西泮
• 英文名: 3-Hydroxyphenazepam
• CAS号: 70030-11-4
• 分子量: 365.61
• 密度: 1.7±0.1 g/cm3
• 沸点: 544.5±50.0 °C at 760 mmHg
• 分子式: C₁₅H₁₀BrClN₂O₂
• 熔点: N/A
• 闪点: 283.1±30.1 °C

3-羟基芬纳西泮用途

3-Hydroxyphenazepam 是 Cinazepam 的活性代谢物。Cinazepam 是一种 GABAA 受体激动剂。3-Hydroxyphenazepam 可抑制突触体转运蛋白介导的 [3H]GABA 摄取。

3-羟基芬纳西泮名称

• 中文名: 3-羟基芬纳西泮
• 英文名: 7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one

3-羟基芬纳西泮生物活性

• 描述: 3-Hydroxyphenazepam 是 Cinazepam 的活性代谢物。Cinazepam 是一种 GABAA 受体激动剂。3-Hydroxyphenazepam 可抑制突触体转运蛋白介导的 [3H]GABA 摄取。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Borisova T, et, al. GABAA receptor agonist cinazepam and its active metabolite 3-hydroxyphenazepam act differently at the presynaptic site. Eur Neuropsychopharmacol. 2021 Apr;45:39-51.

3-羟基芬纳西泮物理化学性质

• 密度: 1.7±0.1 g/cm3
• 沸点: 544.5±50.0 °C at 760 mmHg
• 分子式: C₁₅H₁₀BrClN₂O₂
• 分子量: 365.61
• 闪点: 283.1±30.1 °C
• 精确质量: 363.961395
• PSA: 65.18000
• LogP: 2.46
• InChIKey: KRJKJUWAZOWXNV-UHFFFAOYSA-N
• SMILES: O=C1Nc2ccc(Br)cc2C(c2ccccc2Cl)=NC1O
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.712

3-羟基芬纳西泮靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

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3-羟基芬纳西泮英文别名

• 3-Hydroxyfenazepam
• 7-bromo-5-(2-chlorophenyl)-3-hydroxy-1,2-dihydro-3H-1,4-benzodiazepin-2-one
• 3-Oxyfenazepam
• 7-bromo-5-(2-chloro-phenyl)-3-hydroxy-1,3-dihydro-benzo[e][1,4]diazepin-2-one
• 7-Bromo-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-1,4-benzodiazepin-2-one
• 3-Hydroxyphenazepam