2,4,6-Trisubstituted pyrimidines have been synthesized using various methods and procedures including the reaction of amidines with α,β-unsaturated ketones, 11 dimerization–oxidative fragmentation of aryl-β-arylvinylimines, 12 one-pot condensation of β-dicarbonyl compounds, NH 4 OAc and aldehydes, 13 condensation of phenacyldimethylsulfonium salts, aldehydes, and ammonia, 14 reaction of alkynes and nitriles in the presence of TfOH, 15 rearrangement of 2,4,5- ...