Phytochemistry

Effect of natural and synthetic benzyl benzoates on calmodulin

B Rivero-Cruz, I Rivero-Cruz, R Rodríguez-Sotres…

文献索引：Rivero-Cruz, Blanca; Rivero-Cruz, Isabel; Rodriguez-Sotres, Rogelio; Mata, Rachel Phytochemistry, 2007 , vol. 68, # 8 p. 1147 - 1155

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被引用次数: 23

摘要

The present investigation describes the effect of the spasmolytic benzylbenzoates 1–9 from Brickellia veronicifolia on CaM using a functional in vitro enzymatic assay. Bovine brain PDE1 was used as a monitoring enzyme. The most active natural inhibitors of the system CaM–PDE1 were benzyl benzoates 3–5, which inhibited the activity of PDE1 in a concentration-dependent manner. In addition, three series of analogs of compound 4, ...