Organic letters

Palladium-Catalyzed Benzylation of Carboxylic Acids with Toluene via Benzylic C–H Activation

H Liu, G Shi, S Pan, Y Jiang, Y Zhang

文献索引：Liu, Hongqiang; Shi, Guangfa; Pan, Shulei; Jiang, Yuyu; Zhang, Yanghui Organic Letters, 2013 , vol. 15, # 16 p. 4098 - 4101

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被引用次数: 50

摘要

Direct benzylation of carboxylic acids with toluene has been developed via palladium- catalyzed C–H acyloxylation under 1 atm of oxygen. This reaction demonstrates good functional group tolerance and high yields, providing a facile, atom-economic, and efficient method for the synthesis of benzyl esters.

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