Synthesis and hypoxic–cytotoxic activity of some 3-amino-1, 2, 4-benzotriazine-1, 4-dioxide derivatives

F Jiang, B Yang, L Fan, Q He, Y Hu

文献索引：Jiang, Faqin; Yang, Bo; Fan, Lingling; He, Qiaojun; Hu, Yongzhou Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 16 p. 4209 - 4213

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被引用次数: 13

摘要

A series of 3-amino-1, 2, 4-benzotriazine-1, 4-dioxide derivatives 1 have been synthesized and evaluated for their cytotoxic activity in vitro against human leukemia cell lines: Molt-4, K562, HL60, human liver cancer cell Hep-G2, human prostate cancer cell PC-3 in hypoxia. Most of the compounds showed more potent activity than TPZ. Compounds 1i and 1m displayed encouraging superior activity against Molt-4 and HL-60 cell lines. Three ...