Modulation of GABAA-receptors by honokiol and derivatives: subtype selectivity and structure–activity relationship

B Taferner, W Schuehly, A Huefner…

文献索引：Schuehly, Wolfgang; Huefner, Antje; Pferschy-Wenzig, Eva M.; Prettner, Elke; Adams, Michael; Bodensieck, Antje; Kunert, Olaf; Oluwemimo, Asije; Haslinger, Ernst; Bauer, Rudolf Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 13 p. 4459 - 4465

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被引用次数: 34

摘要

A series of 31 analogues of the neolignan honokiol (a major constituent of Magnolia officinalis) was synthesized, and their effects on GABAA receptors expressed in Xenopus oocytes were investigated. Honokiol enhanced chloride currents (I GABA) through GABAA