European journal of medicinal chemistry

Depsides as non-redox inhibitors of leukotriene B 4 biosynthesis and HaCaT cell growth. 1. Novel analogues of barbatic and diffractaic acid

SK KC, K Müller

文献索引：Kumar, Sunil; Mueller, Klaus European Journal of Medicinal Chemistry, 1999 , vol. 34, # 12 p. 1035 - 1042

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被引用次数: 1

摘要

Aseries of barbatic and diffractaic acid analogues has been synthesized and evaluated as inhibitors of leukotriene B4 (LTB4) biosynthesis and as antiproliferative agents. The 4-O- demethyl barbatic and diffractaic acid derivatives were among the most active compounds in both assays. In particular, ethyl 4-O-demethylbarbatate was the most potent LTB4 biosynthesis inhibitor of this series, with an IC50 value in the submicromolar range. ...