The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood–brain barrier and exhibits anticonvulsive …

…, KA Youdim, MZ Qaiser, C Rice??Evans…

文献索引：Kavvadias, Dominique; Sand, Philipp; Youdim, Kuresh A.; Qaiser, M. Zeeshan; Rice-Evans, Catherine; Baur, Roland; Sigel, Erwin; Rausch, Wolf-Dieter; Riederer, Peter; Schreier, Peter British Journal of Pharmacology, 2004 , vol. 142, # 5 p. 811 - 820

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被引用次数: 142

摘要

2 After chemical synthesis, hispidulin was investigated at recombinant GABAA/BZD receptors expressed by Xenopus laevis oocytes. Concentrations of 50nM and higher stimulated the GABA-induced chloride currents at tested receptor subtypes (a1À3, 5, 6b2g2S) indicating positive allosteric properties. Maximal stimulation at a1b2g2S was observed with 10 mM hispidulin. In contrast to diazepam, hispidulin modulated the ...