Stereoselective synthesis and anti-proliferative effects on prostate cancer evaluation of 5-substituted-3, 4-diphenylfuran-2-ones

…, P Wang, ZT Lin, YC Duan, JX Zheng, HM Liu

文献索引：Liu, Gai-Zhi; Xu, Hai-Wei; Wang, Peng; Lin, Zong-Tao; Duan, Ying-Chao; Zheng, Jia-Xin; Liu, Hong-Min European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 323 - 336

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被引用次数: 5

摘要

Abstract Series of 5-substituted-3, 4-diphenylfuran-2-ones were stereoselectively prepared. Their potential anti-proliferative effects on prostate cancer and some of their cyclooxygenases (COXs) inhibitory activities were evaluated. Structure–activity relationship (SAR) data, acquired by substituent modification at the para-position and ortho-position of the C-3 phenyl ring and 5-substituted modification of the central furanone, showed that 3-( ...