Tetrahedron letters

Asymmetric total syntheses of (−)-tylophorine via the highly enantioselective intramolecular double michael reaction

M Ihara, Y Takino, K Fukumoto, T Kametani

文献索引：Ihara, Masataka; Takino, Yoshinobu; Fukumoto, Keiichiro; Kametani, Tetsuji Tetrahedron Letters, 1988 ,  vol. 29,  # 33  p. 4135 - 4138

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被引用次数: 25

摘要

Abstract Asymmetric total synthesis of (−)-tylophorine (2) was achieved with a high enantioselectivity through the intramolecular double Michael reaction of the α, β-unsaturated ester (8) having a novel chiral auxiliary with tert.-butyldimethylsilyl trifluoromethanesulfonate and Et 3 N.