Abstract Asymmetric total synthesis of (−)-tylophorine (2) was achieved with a high enantioselectivity through the intramolecular double Michael reaction of the α, β-unsaturated ester (8) having a novel chiral auxiliary with tert.-butyldimethylsilyl trifluoromethanesulfonate and Et 3 N.
![(13aR,14S)-2,3,6,7-tetramethoxy-9-oxo-9,11,12,13,13a,14-hexahydrodibenzo[f,h]pyrrolo[1,2-b]isoquinoline-14-carboxylic acid Structure](https://image.chemsrc.com/caspic/345/121250-60-0.png)
