Palladium-Catalyzed Double Carbonylation Using Near Stoichiometric Carbon Monoxide: Expedient Access to Substituted 13C2-Labeled Phenethylamines

…, AT Lindhardt, A Modvig, T Skrydstrup

文献索引：Nielsen, Dennis U.; Taaning, Rolf H.; Lindhardt, Anders T.; Gogsig, Thomas M.; Skrydstrup, Troels Organic Letters, 2011 , vol. 13, # 16 p. 4454 - 4457

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被引用次数: 41

摘要

A novel and general approach for 13C2-and 2H-labeled phenethylamine derivatives has been developed, based on a highly convergent single-step assembly of the carbon skeleton. The efficient incorporation of two carbon-13 isotopes into phenethylamines was accomplished using a palladium-catalyzed double carbonylation of aryl iodides with near stoichiometric carbon monoxide.